Research Associate I/II, NGS and Molecular Biology Job at Flagship Pioneering, Inc.
About Alltrna
Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.
Alltrna is the world's first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.
About The Role
Come join us and be an integral part of building our Next-Generation Sequencing (NGS) core in Alltrna's tRNA Discovery Platform! We are seeking to hire a highly motivated, organized, and enthusiastic research associate to join our Computational and Molecular Biology team. The candidate will be responsible for supporting NGS projects throughout the company, with the opportunity to work with and learn from multiple teams within Alltrna. This NGS pipeline, which covers workflows from early development to full implementation, is crucial for company initiatives and requires a high level of organization and attention to detail. The successful candidate should be able to work effectively in a team-oriented group and is accustomed to consistently delivering high-quality data on a timeline.
Core Responsibilities
- Prepare and sequence many types of NGS libraries to support key company objectives and results.
- Perform RNA extractions from a wide variety of tissue samples and cells.
- Participate in designing and establishing the systems and practices used to operate Alltrna's NGS core.
- Operate and maintain Illumina NextSeq 2000.
- Independently operate automation instrumentation, including a KingFisher Magnetic Particle Processor and a Biomek Liquid Handler.
- Develop process improvement of current NGS workflows and procedures.
- Troubleshoot problems and participate in new technology evaluation and implementation.
- Document samples, internally track experiment status, interpret data, and clearly communicate your results within Alltrna.
- Diligently maintain all reagents and supplies needed for sequencing experiments.
Qualifications and Skills
- BS/MS in in biology, cell biology, molecular biology, or a related discipline with 2+ years of lab experience, preferably in biotech industry.
- Experience working with nucleic acids, including RNA & DNA purification from cells and tissue, PCR, and gel electrophoresis.
- Understanding of RNA-seq library preparation and sequencing (Illumina).
- Familiarity with commercially available NGS kits for targeted RNA & DNA sequencing.
- Excellent communication, organization, and presentation skills, with attention to accuracy and technical details.
- Verbal and written communication proficiency in technical and non-technical domains.
- Ability to work effectively as an independent scientist and as part of a team.
- Proficient in following, maintaining, and writing SOPs.
- Exceptional organizational and time management skills.
- Meticulous lab notebook/documentation practices.
The preferred candidate will ideally also possess the following skills:
- Familiarity with NGS instrumentation.
- Experience using an electronic laboratory notebook system (ELN).
- Experience with automated liquid handling platforms (preferably Biomek).
What We'll Offer You
- Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
- A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
- Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
- Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
- Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.
Our Core Values
- Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
- Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
- Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
- Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive 'can-do' attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge dogma.
- Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
- Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
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