Scientist, Cell Biology

ALS Therapy Development Institute (ALS-TDI)

www.als.net

Discovering drugs - until all people with ALS have effective treatments

ALS-TDI is a non-profit biotechnology company focused on the discovery of therapies for the treatment of amyotrophic lateral sclerosis (Lou Gehrig's disease). We are conducting a search for a Scientist-level position to support development of cell-based models of ALS and implementation of chemical and genetic screens for drug target and therapeutic discovery. Job responsibilities include generation of novel induced pluripotent stem cell-based models of ALS for use in in cellular phenotype discovery, screening assay development, and screen automation. The successful candidate will be a highly motivated, detail-oriented individual with strong interest in biomedical research

RESPONSIBILITIES:

• Generate iPSC-based models of ALS using patient-derived fibroblasts and genome edited cell lines
• Perform neural differentiations to generate cells for phenotype discovery
• Design, implement, and oversee experiments
• Analyze and present data to the Cell Biology team and company-wide meetings
• Proactively review the scientific field to identify and share new scientific findings, ideas, and methods with other researchers

REPORTS TO: Director of Cell Biology

WORK LOCATION: Watertown, MA, 02472

WORK SCHEDULE: This position is full-time, Monday to Friday, 9-5 pm (with occasional short weekend shifts depending on ongoing cell work)

QUALIFICATIONS:

• MS/MA or Ph.D. in Molecular and Cell Biology or a related discipline, with mammalian cell culture experience.
• Must have at least 3-5 years experience
• Experience with general molecular and cellular biology techniques.
• Neurobiology, stem cell biology, cellular immunology, genome editing, cell-based assay development, lab automation or high content cell analysis experience will be a plus.
• Solid teamwork, reliability and ability to work on more than one project under supervision as well as independently.
• Excellent organizational and communication skills are a must.