About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

General Position Summary/Purpose:

The DMPK-BA department in AbbVie Bay Area (ABA), CA is seeking a highly motivated fulltime in vitro ADME Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to support preclinical characterization of drug molecules in Discovery, with specific focus on CYP450 Induction and Uptake Transporter studies. The IVAS team within the DMPK-BA department works very closely with other disciplines (bioanalysis, medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to perform preclinical compound characterization, support clinical evaluation and contribute to IND and NDA filings.

In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays, primarily CYP450 induction to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Key Accountabilities/Core Job Responsibilities:

• Routinely conduct (hands-on) evaluation of CYP450 induction of candidate molecules
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use microplate reader to measure endpoint
• Contribute to other exploratory invitro ADME assay design and discussions
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Use BioELN and GraphPad Prism for data analysis

Qualifications

Education, Qualifications and Experience Requirements (degree, certifications, etc.):

• MS degree (2-5+ years of experience), B.S. (5+ years of experience), or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development
• Prior experience conducting ADME assays and understanding of the concept of drug-drug interaction is preferred
• Prior working experience with human hepatocytes is required
• Working experience with 2D hepatocyte cell culture and spheroid models
• Maintain knowledge of the principles and theories in ADME in general, and CYP450 induction in particular
• Ability to clearly communicate and work collaboratively with others
• Able to independently interpret findings and make presentations at internal and external meetings
• The individual is expected to be proactive, organized, and passionate about ADME/drug disposition

Note: Ultimate title will depend on experience

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

Applicable to California Applicants Only

• The below range is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range and this range is only applicable for jobs to be performed in California. This range may be modified in the future.

• The salary range for this role is posted below

• This job is eligible to participate in our short-term incentive program

• This job is eligible to participate in our long-term incentive programs

• We offer comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

• Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law.

  
  

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.