Position Summary:

Tessera Therapeutics is seeking an enthusiastic and experienced scientist to fulfil the Scientist/Senior Scientist of Proteomics role in our DMPK group. The candidate will develop, validate, and employ LC/MS based proteomics approaches to analyze biological samples and to discover biomarkers to support research, non-clinical, and clinical development programs for a variety of therapeutic indications. The ideal candidate must have excellent communication skills and be willing to work in a highly dynamic and fast-paced work environment.

Key Responsibilities:

• Develop, optimize, and validate targeted/global proteomics methods for quantitation of proteins in various biological matrices including biofluids, tissues and cells.
• Design and execute proteomics experiments from sample preparation, LC-MS/MS operation to data analysis & interpretation.
• Discover and validate potential biomarker for supporting preclinical and clinical programs.
• Establish, optimize, and maintain the workflow of proteomics studies.
• Write proteomic reports and contribute to regulatory documents for IND/CTA filings.
• Provide maintenance, quality control and troubleshooting of Orbitrap mass spectrometer as well as HPLC/nano-LC systems.

Basic Qualifications:

• PhD in a biological or related discipline e.g., Biology, Biochemistry, Chemistry, Biotechnology or Pharmaceutical Science, with 0-3 years (Scientist) or 3+ years (Senior Scientist) of industry experience. Postdoc experience is a plus.
• Experience in LC-MS based proteomics is required.
• Excellent knowledge and hands-on experience in proteomics sample preparation techniques such as immuno-protein/peptide enrichment and LC-MS based method development and data processing for protein characterization and quantification applications.
• Extensive experience in protein isolation and purification from cells, tissues, and biofluids.
• High level of proficiency in a variety of quantitative proteomics techniques -TMT, SILAC, label-free quantification approaches and peptide fragmentation methods is preferred.
• Proficiency of using one of Thermo Orbitrap mass spectrometers: Q Exactive series or Exploris series is preferred.
• Experience in using Xcalibur, Skyline, Proteome Discoverer, or BioPharma software.
• Excellent organizational and communication skills.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment
• Experience in Triple Quadropole LC-MS is a plus.
• Experience with downstream statistical and bioinformatics analysis is a plus.

More About Flagship Pioneering

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.