Principal Scientist, Protein Engineering, Moderna Genomics Job at Moderna Therapeutics
The Role:
As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA. mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and nonviral gene therapies. It is our intention to be an industry leader in genomic medicines.
Moderna Genomics has an exciting opening for a discovery-focused scientist to engineer, innovate and optimize novel gene editing systems at mGx, as part of the Protein Engineering group for Genome Editing Innovation (GEI). The candidate will have the ability to drive the engineering of novel gene-editing technologies such as DNA/RNA-modifying enzymes.
The ideal candidate will have expertise in at least one of the following areas: rational/structural-guided engineering of proteins and/or RNAs; directed evolution of enzymes using in vitro and/or in vivo assays or biophysical characterization (e.g., X-ray crystallography, Cryo-EM, single-molecular assay) and manipulation of enzymes to understand and improve their activities.
She/he/they will collaborate with internal and external partners to engineer our lead gene-editing systems to enable best-in-class efficiency and precision, turning them into life-saving medicines. She/he/they will have the unique opportunity to work with VP and head of GEI to build and develop a team to engineer, design, and evolve novel gene editing protein/RNAs. The candidate will collaborate with the broader mGx team on translational development of these systems leveraging Moderna’s scalable mRNA and non-viral delivery platforms, working at the cutting edge of gene editing research and directly impacting mGx’s innovation efforts.
Here’s What You’ll Do:
Perform PoC experiments to characterize the activity and property of lead proprietary gene-editing systems, using biophysical, biochemical and/or cell-based methods.
Work with gene-editing system discovery scientists on optimizing lead candidates into high-efficiency, high-precision gene-editors.
Propose, design, and implement experiments in one of the following areas: (1) rational/structural-guided protein engineering, or (2) using directed evolution to improve protein/RNA function, in collaboration with protein engineering team members.
Work with Quantitative Biology and Data Science teams on design strategies for AI-assisted protein design and engineering.
Work with the Head of Gene Editing Innovation to build a team to develop, improve, and optimize one or more novel gene editing technologies.
Act as a liaison and collaborate in a matrixed organization to optimize gene editing efficiency
Collaborate with internal teams to understand therapeutic editing needs
Document results in electronic notebooks
Analyze and synthesize results to assess future directions
Present and discuss data to internal groups
Here’s What You’ll Bring to the Table:
PhD in Biology, Biochemistry, Biophysics, Chemistry, Bioengineering, or equivalent field
Extensive experience in enzyme/protein engineering in an academic or industrial environment
Proven track record of design and development of assays or strategies for characterizing and improving protein and/or RNA function
Extensive experience in one or more of the following areas: protein structure, biochemical techniques, and enzyme activity assays
Conversant in computationally informed protein design
Excellent interpersonal, verbal, and written communication skills
Strong desire to work on early-stage technology development, implementing creative thinking to build mGx’s genome-editing toolkit and patent portfolio
Additional positives:
Experience with gene editing system technology development
Experience with high-throughput protein/RNA activity measurements
Experience with sequencing-based genomics assays
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!
Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible . Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.
About Moderna
In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.
Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com .
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. #LI-JL2
-
Please Note :
caminobluff.com is the go-to platform for job seekers looking for the best job postings from around the web. With a focus on quality, the platform guarantees that all job postings are from reliable sources and are up-to-date. It also offers a variety of tools to help users find the perfect job for them, such as searching by location and filtering by industry. Furthermore, caminobluff.com provides helpful resources like resume tips and career advice to give job seekers an edge in their search. With its commitment to quality and user-friendliness, Site.com is the ideal place to find your next job.
As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA. mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and nonviral gene therapies. It is our intention to be an industry leader in genomic medicines.
Moderna Genomics has an exciting opening for a discovery-focused scientist to engineer, innovate and optimize novel gene editing systems at mGx, as part of the Protein Engineering group for Genome Editing Innovation (GEI). The candidate will have the ability to drive the engineering of novel gene-editing technologies such as DNA/RNA-modifying enzymes.
The ideal candidate will have expertise in at least one of the following areas: rational/structural-guided engineering of proteins and/or RNAs; directed evolution of enzymes using in vitro and/or in vivo assays or biophysical characterization (e.g., X-ray crystallography, Cryo-EM, single-molecular assay) and manipulation of enzymes to understand and improve their activities.
She/he/they will collaborate with internal and external partners to engineer our lead gene-editing systems to enable best-in-class efficiency and precision, turning them into life-saving medicines. She/he/they will have the unique opportunity to work with VP and head of GEI to build and develop a team to engineer, design, and evolve novel gene editing protein/RNAs. The candidate will collaborate with the broader mGx team on translational development of these systems leveraging Moderna’s scalable mRNA and non-viral delivery platforms, working at the cutting edge of gene editing research and directly impacting mGx’s innovation efforts.
Here’s What You’ll Do:
Perform PoC experiments to characterize the activity and property of lead proprietary gene-editing systems, using biophysical, biochemical and/or cell-based methods.
Work with gene-editing system discovery scientists on optimizing lead candidates into high-efficiency, high-precision gene-editors.
Propose, design, and implement experiments in one of the following areas: (1) rational/structural-guided protein engineering, or (2) using directed evolution to improve protein/RNA function, in collaboration with protein engineering team members.
Work with Quantitative Biology and Data Science teams on design strategies for AI-assisted protein design and engineering.
Work with the Head of Gene Editing Innovation to build a team to develop, improve, and optimize one or more novel gene editing technologies.
Act as a liaison and collaborate in a matrixed organization to optimize gene editing efficiency
Collaborate with internal teams to understand therapeutic editing needs
Document results in electronic notebooks
Analyze and synthesize results to assess future directions
Present and discuss data to internal groups
Here’s What You’ll Bring to the Table:
PhD in Biology, Biochemistry, Biophysics, Chemistry, Bioengineering, or equivalent field
Extensive experience in enzyme/protein engineering in an academic or industrial environment
Proven track record of design and development of assays or strategies for characterizing and improving protein and/or RNA function
Extensive experience in one or more of the following areas: protein structure, biochemical techniques, and enzyme activity assays
Conversant in computationally informed protein design
Excellent interpersonal, verbal, and written communication skills
Strong desire to work on early-stage technology development, implementing creative thinking to build mGx’s genome-editing toolkit and patent portfolio
Additional positives:
Experience with gene editing system technology development
Experience with high-throughput protein/RNA activity measurements
Experience with sequencing-based genomics assays
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:
- Vacation, sick time and holidays
- Volunteer time to participate within your community
- D iscretionary year-end shutdown
- Paid sabbatical after 5 years; every 3 years thereafter
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!
Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible . Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.
About Moderna
In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.
Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com .
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. #LI-JL2
-
Please Note :
caminobluff.com is the go-to platform for job seekers looking for the best job postings from around the web. With a focus on quality, the platform guarantees that all job postings are from reliable sources and are up-to-date. It also offers a variety of tools to help users find the perfect job for them, such as searching by location and filtering by industry. Furthermore, caminobluff.com provides helpful resources like resume tips and career advice to give job seekers an edge in their search. With its commitment to quality and user-friendliness, Site.com is the ideal place to find your next job.